Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Agomelatine (hydrochloride) (Standard)

Agomelatine (hydrochloride) (Standard) is the analytical standard of Agomelatine (hydrochloride) . This product is intended for research and analytical applications. Agomelatine hydrochloride (S-20098 hydrochloride) is a specific agonist of MT1 and MT2 receptors with Kis of 0.1, 0.06, 0.12, and 0.27 nM for CHO-hMT1, HEK-hMT1, CHO-hMT2, and HEK-hMT2, respectively[1]. Agomelatine hydrochloride is a selective 5-HT2C receptor antagonist with pKis of 6.4 and 6.2 at native (porcine) and cloned, human 5-HT2C receptors, respectively[2].

Product Specifications

CAS Number

1176316-99-6

UNSPSC

12352100

Target

5-HT Receptor; Endogenous Metabolite; Melatonin Receptor; Reference Standards

Related Pathways

GPCR/G Protein; Metabolic Enzyme/Protease; Neuronal Signaling; Others

Field of Research

Neurological Disease

Smiles

CC(NCCC1=C2C=C(OC)C=CC2=CC=C1)=O.Cl

Molecular Formula

C15H18ClNO2

Molecular Weight

279.76

References & Citations

[1]Audinot V, et al. New selective ligands of human cloned melatonin MT1 and MT2 receptors. Naunyn Schmiedebergs Arch Pharmacol. 2003 Jun;367 (6) :553-61.|[2]Millan MJ, et al. The novel melatonin agonist agomelatine (S20098) is an antagonist at 5-hydroxytryptamine2C receptors, blockade of which enhances the activity of frontocortical dopaminergic and adrenergic pathways. J Pharmacol Exp Ther. 2003 Sep;306 (3) :954-64.|[3]Aguiar CC, et al. Effects of agomelatine on oxidative stress in the brain of mice after chemically induced seizures. Cell Mol Neurobiol. 2013 Aug;33 (6) :825-35.

Shipping Conditions

Room temperature

Scientific Category

Reference Standards

Available Sizes

Frequently Asked Questions

More Discoveries

Explore Other Products

Browse additional items from our catalog

Tissue FFPE Sections, Breast
CS706168 5x 5 µm

Tissue FFPE Sections, Breast

Sign In for Pricing
View Details
Guanine-4,5,6-13C3-7-15N
TRC-G584971-10MG 10 mg

Guanine-4,5,6-13C3-7-15N

Sign In for Pricing
View Details
Frozen Tissue Sections, Colon
CS639538 5x 5 µm

Frozen Tissue Sections, Colon

Sign In for Pricing
View Details
Human Lambda Light Chain (ICO-106), CF740 conjugate, 0.1mg/mL
BNC740019-100 1x 100 µL

Human Lambda Light Chain (ICO-106), CF740 conjugate, 0.1mg/mL

Sign In for Pricing
View Details
GLYATL1 Human Gene Knockout Kit (CRISPR)
KN417505 1 Kit

GLYATL1 Human Gene Knockout Kit (CRISPR)

Sign In for Pricing
View Details
CEACAM6 Mouse Monoclonal Antibody [A1E3]
EM1901-69 100 µL

CEACAM6 Mouse Monoclonal Antibody [A1E3]

Sign In for Pricing
View Details