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BChE-IN-39

BChE-IN-39 (Compound 7c) is a selective inhibitor for butyrylcholinesterase (BChE) with an IC50 of 0.08 μM (IC50=3.98 μM for AChE) . BChE-IN-39 downregulates the GSK-3β expression, inhibits the hyperphosphorylation of tau protein[1].

Product Specifications

UNSPSC

12352005

Target

Cholinesterase (ChE)

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Smiles

FC1=CC(C[N+]2=CC=CC(CNC(C3=CC=C(CN(C(C4=C5C=CC=C4)=O)C5=O)C=C3)=O)=C2)=CC=C1.[Cl-]

Molecular Formula

C29H23ClFN3O3

Molecular Weight

515.96

References & Citations

[1]Noori M, et al., Isoindolinedione-Benzamide Pyridinium Derivatives for Targeting Alzheimer's Disease. ACS Omega. 2024 Nov 25;9 (49) :48032-48043.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

AChE; BChE

Frequently Asked Questions

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