MRS8209
MRS8209 is the antagonist for serotonin receptor with a Ki of 4.27 nM for 5-HT2BR. MRS8209 exhibits protective effect on pressure at airway opening (PAO), and can be used in research of pulmonary fibrosis[1].
Product Specifications
UNSPSC
12352005
Target
5-HT Receptor
Related Pathways
GPCR/G Protein; Neuronal Signaling
Field of Research
Cardiovascular Disease
Smiles
O[C@@H]1[C@H](O)[C@@]2(C#N)[C@H](C2)[C@H]1N3C(N=C(I)N=C4NC5CCCC5)=C4N=C3
Molecular Formula
C17H19IN6O2
Molecular Weight
466.28
References & Citations
[1]Tosh DK, et al., Potent and Selective Human 5-HT2B Serotonin Receptor Antagonists: 4'-Cyano- (N) -methanocarba-adenosines by Synthetic Serendipity. J Med Chem. 2024 Dec 12;67 (23) :21264-21291.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
α-1 microglobulin
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