RORγt inverse agonist 34
RORγt inverse agonist 34 (compound 5a) is a RORγt inverse agonist with an IC50 of 0.094 μM for RORγt-LBD. RORγt inverse agonist 34 is used for psoriasis research[1].
Product Specifications
CAS Number
[2247604-77-7]
UNSPSC
12352005
Target
ROR
Related Pathways
Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Smiles
O=S(N1CCCC2=CC(NC3=CC4=C(C=C3)C(CCC4)=O)=CC=C21)(N(CC5=CC=C(C=C5)C(C)(C)C)C)=O
Molecular Formula
C31H37N3O3S
Molecular Weight
531.71
References & Citations
[1]Lv L, Chen B, et.al. Discovery of Novel N-Sulfonamide-tetrahydroquinolines as Potent Retinoic Acid Receptor-Related Orphan Receptor γt (RORγt) Inverse Agonists for the Treatment of Psoriasis. J Med Chem. 2024 Dec 12;67 (23) :21400-21420.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 3
Isoform
RORγ
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