SHO1122147

SHO1122147 (Compound 7m) affects the mitochondrial electron transport chain, exhibits mitochondrial uncoupling activity (EC50=3.6 μM), and increases the oxygen consumption rate (OCR=69%) and promotes cellular respiration. SHO1122147 is orally active, and can be used in reaearch of obesity and metabolic dysfunction-associated steatohepatitis (MASH) [1].

Product Specifications

UNSPSC

12352005

Target

Mitochondrial Metabolism

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Smiles

OC1=C(NC2=CC=C(C3=CC=CC(Cl)=C3)C=C2)C=NC4=NON=C41

Molecular Formula

C17H11ClN4O2

Molecular Weight

338.75

References & Citations

[1]Foutz MA, et al., Design, Synthesis, and Biological Evaluation of [1,2,5]Oxadiazolo[3,4-b]pyridin-7-ol as Mitochondrial Uncouplers for the Treatment of Obesity and Metabolic Dysfunction-Associated Steatohepatitis. J Med Chem. 2024 Dec 12;67 (23) :21486-21504.