SHO1122147
SHO1122147 (Compound 7m) affects the mitochondrial electron transport chain, exhibits mitochondrial uncoupling activity (EC50=3.6 μM), and increases the oxygen consumption rate (OCR=69%) and promotes cellular respiration. SHO1122147 is orally active, and can be used in reaearch of obesity and metabolic dysfunction-associated steatohepatitis (MASH) [1].
Product Specifications
UNSPSC
12352005
Target
Mitochondrial Metabolism
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Smiles
OC1=C(NC2=CC=C(C3=CC=CC(Cl)=C3)C=C2)C=NC4=NON=C41
Molecular Formula
C17H11ClN4O2
Molecular Weight
338.75
References & Citations
[1]Foutz MA, et al., Design, Synthesis, and Biological Evaluation of [1,2,5]Oxadiazolo[3,4-b]pyridin-7-ol as Mitochondrial Uncouplers for the Treatment of Obesity and Metabolic Dysfunction-Associated Steatohepatitis. J Med Chem. 2024 Dec 12;67 (23) :21486-21504.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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