VEGFR-2-IN-58

VEGFR-2-IN-58 (Compound 7b) inhibits VEGFR-2 with an IC50 of 42.5 nM. VEGFR-2-IN-58 displays selective cytotoxicity against cancer cells. VEGFR-2-IN-58 shows cellular growth arrest at the G2/M phase in cancer cells. VEGFR-2-IN-58 induces cancer cells Apoptosis, increasing BAX expression and reducing Bcl2 expression. VEGFR-2-IN-58 inhibits wound closure in cancer cells[1].

Product Specifications

UNSPSC

12352005

Target

Apoptosis; VEGFR

Related Pathways

Apoptosis; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Smiles

N#CC1=C(/N=C/NC2=CC=C(Cl)C=C2)OC(C3=CC=CC=C3)=C1C4=CC=CC=C4

Molecular Formula

C24H16ClN3O

Molecular Weight

397.86

References & Citations

[1]Abd El-Haleem AH, et al. Furan- and Furopyrimidine-Based Derivatives: Synthesis, VEGFR-2 Inhibition, and In Vitro Cytotoxicity. ACS Med Chem Lett. 2024 Nov 25;15 (12) :2150-2157.