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HPK1-IN-55

HPK1-IN-55 (compound 19) is a selective and orally active hematopoietic progenitor kinase 1 (HPK1) inhibitor with an IC50 of 637-fold vs GCK-like kinase and >1022-fold vs LCK) . HPK1-IN-55 has anticancer effects[1].

Product Specifications

CAS Number

3048537-58-9

UNSPSC

12352005

Target

MAP4K

Related Pathways

MAPK/ERK Pathway

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Inflammation/Immunology

Smiles

COC1=CC(NC2=CC=C3C4(N(CC3=N2)C)CCN(CC4)C5COC5)=C(N=C1C6=C(C7=CC=C6)N=CN7C)C(N)=O

Molecular Formula

C30H34N8O3

Molecular Weight

554.64

References & Citations

[1]Peng J, et.al. Discovery of Pyridine-2-Carboxamides Derivatives as Potent and Selective HPK1 Inhibitors for the Treatment of Cancer. J Med Chem. 2024 Dec 12;67 (23) :21520-21544.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

MAP4K1/HPK1

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