Proteasome-IN-6
Proteasome-IN-6 (Compound J-80) inhibits the β5 catalytic subunit of the Trypanosoma brucei 20S proteasome, inibits T. b. brucei, T. b. gambiense and T. b. rhodesiense with EC50s of 157 nM, 220 nM and 156 nM, respectively. Proteasome-IN-6 exhibits antitrypanosomal activity in mouse model[1].
Product Specifications
CAS Number
[3063720-23-7]
UNSPSC
12352005
Target
Parasite; Proteasome
Related Pathways
Anti-infection; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Infection
Smiles
CCCCCC(N[C@H](CC(N(CC)CC)=O)C(N[C@@H](CC1=CC=C(F)C=C1)C(N[C@@H](CC2=CC=C(F)C=C2F)C([C@@]3(C)CO3)=O)=O)=O)=O
Molecular Formula
C35H45F3N4O6
Molecular Weight
674.75
References & Citations
[1]Liu LJ, et al., Carmaphycin B-Based Proteasome Inhibitors to Treat Human African Trypanosomiasis: Structure-Activity Relationship and In Vivo Efficacy. ACS Infect Dis. 2024 Dec 13;10 (12) :4182-4193.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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