(R) -cGAS-IN-4
(R) -cGAS-IN-4 (Compound 77A*) is the R-enantiomer of cGAS-IN-4 (HY-170362) . cGAS-IN-4 is an orally active inhibitor for cyclic GMP-AMP synthase (cGAS) [1].
Product Specifications
CAS Number
[2987886-48-4]
UNSPSC
12352005
Target
Cyclic GMP-AMP Synthase
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Purity
99.94
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
C[C@@H]1C(C2=CC=C3Cl)=C(CCN1C(C4=NC=C(OCCO)C=N4)=O)NC2=C3Cl
Molecular Formula
C19H18Cl2N4O3
Molecular Weight
421.28
References & Citations
[1]Ramsay Beveridge, et al. Hexahydropyrido[4,3-b]indolyl ketone derivatives useful as cgas modulators. WO2023183275A1.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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