MTHFD2-IN-5
MTHFD2-IN-5 (Compound 16e) is a selective inhibitor for MTHFD2 with an IC50 of 66 nM. MTHFD2-IN-5 inhibits the proliferation of MOLM-14 with a GI50 of 720 nM. MTHFD2-IN-5 exhibits antitumor efficacy in mouse models[1].
Product Specifications
CAS Number
3068001-31-7
UNSPSC
12352005
Target
Methylenetetrahydrofolate Dehydrogenase (MTHFD)
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
OC(CC[C@@H](C(O)=O)NC(C1=CC(Cl)=C(C=C1)NC(NC2=C(NC(N)=NC2=O)N)=O)=O)=O
Molecular Formula
C17H18ClN7O7
Molecular Weight
467.82
References & Citations
[1]Chang HH, et al., Development of Potent and Selective Inhibitors of Methylenetetrahydrofolate Dehydrogenase 2 for Targeting Acute Myeloid Leukemia: SAR, Structural Insights, and Biological Characterization. J Med Chem. 2024 Dec 12;67 (23) :21106-21125.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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