UCB9386
UCB9386 is the selective and brain penetrant inhibitor for Nuak1 with a pIC50 of 10.1. UCB9386 inhibits Nuak2 and Kak2 with an inhibition rate of ca. 50% at 10 nM[1].
Product Specifications
UNSPSC
12352005
Target
AMPK; JAK
Related Pathways
Epigenetics; JAK/STAT Signaling; PI3K/Akt/mTOR; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Field of Research
Cancer
Purity
99.89
Solubility
DMSO : 83.33 mg/mL (ultrasonic; adjust pH to 7 with 1 M HCL)
Smiles
C[C@H](C1=CC=CC=C1)N(C(C(N2CC3(CN(C)C3)C2)=N4)=O)C5=C4C=NC(C6=CN=C7C=CC=NN76)=C5
Molecular Formula
C27H26N8O
Molecular Weight
478.55
References & Citations
[1]Poullennec KG, et al., Discovery of UCB9386: A Potent, Selective, and Brain-Penetrant Nuak1 Inhibitor Suitable for In Vivo Pharmacological Studies. J Med Chem. 2024 Dec 12;67 (23) :20879-20910.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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