PROTAC SMARCA2/4 degrader-36
PROTAC SMARCA2/4 degrader-36 (Compound 29) is an effective dual degrader of SMARCA2/4, with DC50 values of 0.22 nM and 0.85 nM for SMARCA2 and SMARCA4, respectively. PROTAC SMARCA2/4 degrader-36 has anti-cell proliferation activity (Pink: Target Protein Ligand (HY-170354) ; Black: Linker (HY-W895794) ; Blue: E3 Ligase Ligand (HY-170353) ; E3 Ligase Ligand-Linker Conjugate (HY-170356) ) [1].
Product Specifications
CAS Number
[3033588-00-7]
UNSPSC
12352005
Target
Epigenetic Reader Domain; PROTACs
Related Pathways
Epigenetics; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
Molecular Formula
C53H62ClN9O4S
Molecular Weight
956.64
References & Citations
[1]Li Z, et al. Discovery of Potent, Highly Selective, and Efficacious SMARCA2 Degraders[J]. Journal of Medicinal Chemistry, 2024.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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