PROTAC SMARCA2/4 degrader-36
PROTAC SMARCA2/4 degrader-36 (Compound 29) is an effective dual degrader of SMARCA2/4, with DC50 values of 0.22 nM and 0.85 nM for SMARCA2 and SMARCA4, respectively. PROTAC SMARCA2/4 degrader-36 has anti-cell proliferation activity (Pink: Target Protein Ligand ; Black: Linker (HY-W895794) ; Blue: E3 Ligase Ligand (HY-170353) ; E3 Ligase Ligand-Linker Conjugate (HY-170356) ).
Product Specifications
CAS Number
3033588-00-7
UNSPSC
12352005
Target
Epigenetic Reader Domain; PROTACs
Related Pathways
Epigenetics; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
ClC1=CC=CC(N(C(C=CC(C2CCN(C[C@H]3CC[C@H](C4=CN([C@H](C(N5C[C@H](O)C[C@H]5C(N[C@@H](C)C6=CC=C(C7=C(C)N=CS7)C=C6)=O)=O)C(C)C)N=N4)CC3)CC2)=C8)=C8C9(C)C)C9=N%10)=C1C%10=O
Molecular Formula
C53H62ClN9O4S
Molecular Weight
956.64
References & Citations
[1]Li Z, et al. Discovery of Potent, Highly Selective, and Efficacious SMARCA2 Degraders[J]. Journal of Medicinal Chemistry, 2024.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
H6987 96 Tests
Trafficking protein particle complex subunit 1 (TRAPPC1) Human ELISA Kit
Sign In for Pricing
View Details