PROTAC SMARCA2 degrader-32
PROTAC SMARCA2 degrader-32 (Compound 27) is the degrader for SMARCA2 with a DC50 of 1.3 nM. PROTAC SMARCA2 degrader-32 inhibits the proliferation of lung cancer cell NCI-H838 with a GI50 of 34 nM[1]. (Pink: ligand for target protein SMARCA2 ligand-11 (HY-170349) ; Black: linker (HY-W895794) ; Blue: ligand for E3 ligase VHL (HY-170348) )
Product Specifications
CAS Number
[3033586-50-1]
UNSPSC
12352005
Target
PROTACs; SWI/SNF Complex
Related Pathways
Cell Cycle/DNA Damage; PROTAC
Field of Research
Cancer
Smiles
CC1(C(N(C2=CC=CC(Cl)=C23)C4=CC(C5CCN(CC5)C[C@@H]6CC[C@@H](C7=CN(N=N7)[C@@H](C(C)(C)C)C(N8[C@@H](C[C@H](C8)O)C(N[C@H](C9=CC=C(C%10=C(N=CS%10)C)C=C9)C)=O)=O)CC6)=CC=C41)=NC3=O)C
Molecular Formula
C54H64ClN9O4S
Molecular Weight
970.66
References & Citations
[1]Li Z, et al., Discovery of Potent, Highly Selective, and Efficacious SMARCA2 Degraders. J Med Chem. 2024 Nov 21.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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