PROTAC ER Degrader-14
PROTAC ER Degrader-14 (compound 86) is a PTORAC-type Estrogen Receptor/ERR degrader, which is composed of E3 ubiquitin ligase ligand (blue part) (S) -Deoxy-thalidomide (HY-168055), PROTAC Linker (black part) N-Boc-piperazine (HY-30105) and target protein ligand (red part) ER ligand-6 (HY-170341) . Among them, E3 ligase + Linker constitute tert-Butyl (S) -4- (2- (2,6-dioxopiperidin-3-yl) -1-oxoisoindolin-5-yl) piperazine-1-carboxylate (HY-W998234) [1].
Product Specifications
CAS Number
[2504911-73-1]
UNSPSC
12352005
Target
Estrogen Receptor/ERR; PROTACs
Related Pathways
PROTAC; Vitamin D Related/Nuclear Receptor
Field of Research
Cancer
Smiles
O=C1N([C@H](C(N2)=O)CCC2=O)CC3=C1C=CC(N4CCN(CC5CCN(C6=CC=C([C@H]7[C@@H](C8=CC=CC=C8)COC9=C7C=CC(O)=C9)C=C6F)CC5)CC4)=C3
Molecular Formula
C44H46FN5O5
Molecular Weight
743.86
References & Citations
[1]Preparation of chroman derivatives having estrogen receptor degradation activity and uses thereof. United States, US10800770 B1 2020-10-13.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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