PROTAC ERα Degrader-10
PROTAC ERα Degrader-10 (Compound 160a) is an orally active degrader for ERα with DC50 of 0.37-1.1 nM, in cells MCF7, T47D and CAMA-1. PROTAC ERα Degrader-10 exhibits antitumor efficacy in mouse model[1]. (Pink: ligand for target protein (HY-170339) ; Black: linker (HY-30105) ; Blue: ligand for E3 ligase Cereblon (HY-168055) )
Product Specifications
CAS Number
[2421260-43-5]
UNSPSC
12352005
Target
Estrogen Receptor/ERR; PROTACs
Related Pathways
PROTAC; Vitamin D Related/Nuclear Receptor
Field of Research
Cancer
Smiles
CC/C(C1=CC=CC=C1)=C(C2=CC=C(N3CCC(CN4CCN(C5=CC(CN([C@H]6CCC(NC6=O)=O)C7=O)=C7C=C5)CC4)CC3)C=C2)\C8=CC=C(O)C=C8
Molecular Formula
C45H49N5O4
Molecular Weight
723.90
References & Citations
[1]Fan J, et al., Novel compounds having estrogen receptor alpha degradation activity and uses thereof. US20200157078.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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