PROTAC AR Degrader-8
PROTAC AR Degrader-8 (Compound NP18) is the PROTAC degrader for androgen receptor (AR), that degrades AR-FL with DC50 of 0.018 μM and 0.14 μM in 22Rv1 cell and LNCaP cell, degrades AR-V7 with DC50 of 0.026 μM in 22Rv1 cell. PROTAC AR Degrader-8 inhibits the proliferation of cancer cell 22Rv1 and LNCaP with IC50 of 0.038 μM and 1.11 μM. PROTAC AR Degrader-8 arrests cell cycle at G2/M phase, induces apoptosis in 22Rv1 cell. PROTAC AR Degrader-8 exhibits anticancer efficacy in mouse and zebrafish model[1]. (Pink: ligand for target protein AR ligand-33 ; Black: linker (HY-W007731) ; Blue: ligand for E3 ligase Cereblon (HY-14658) )
Product Specifications
CAS Number
3044108-04-2
UNSPSC
12352005
Target
Androgen Receptor; Apoptosis; PROTACs
Related Pathways
Apoptosis; PROTAC; Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer
Purity
99.98
Solubility
DMSO : ≥ 100 mg/mL
Smiles
O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=CC=C3NCCOC4=CC=C(C(C)(C5=CC=C(OCC6=NC(N7CCOCC7)=CC=C6)C=C5)C)C=C4)=O
Molecular Formula
C40H41N5O7
Molecular Weight
703.78
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
Colloidal Gold Conjugated Monoclonal Antibody to Human IgG, 10nm
![EGFR (C-term) (incl. pos. control) Mouse Monoclonal Antibody [Clone ID: 13G8]](https://cdn.genprice.uk/products/937/68dd1899061270361e8fb5d9/imageurl/am00047pu-n.webp)
EGFR (C-term) (incl. pos. control) Mouse Monoclonal Antibody [Clone ID: 13G8]
