17alpha-Hydroxywithanolide D

17alpha-Hydroxywithanolide D is the allosteric modulator for NMDA receptor with an IC50 of 44.24 nM. 17alpha-Hydroxywithanolide D exhibits neuroprotective activity and can be used in research of Alzheimer's disease disease[1].

Product Specifications

UNSPSC

12352005

Target

IGluR

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Smiles

CC1[C@@H](C)C(O)O[C@@H]([C@](O)([C@@]2(O)CC[C@@H]3[C@]2(C)CC[C@H]4[C@H]3C[C@@H]5[C@@]6(O5)[C@]4(C)[C@H](O)CC[C@@H]6O)C)C1

Molecular Formula

C28H46O7

Molecular Weight

494.66

References & Citations

[1]Vashisth MK, et al., In-Silico discovery of 17alpha-hydroxywithanolide-D as potential neuroprotective allosteric modulator of NMDA receptor targeting Alzheimer's disease. Sci Rep. 2024 Nov 13;14 (1) :27