4-TM.P
4-TM.P binds to the minor groove of DNA, inhibits proliferation of cancer cell K562 with an IC50 of 25 µM, arrests the cell cycle at G0/G1 phase, and induces apoptosis in cell K562. 4-TM.P can be used in anti-leukemia research[1].
Product Specifications
CAS Number
[2089575-84-6]
UNSPSC
12352005
Target
Apoptosis
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
O=C(C1=NC=CN=C1)OC(C)/C=C/C2=C(C)CCCC2(C)C
Molecular Formula
C18H24N2O2
Molecular Weight
300.40
References & Citations
[1]Jahanbakhsh K, et al., DNA binding, and apoptosis-inducing activities of a β-ionone-derived ester in human myeloid leukemia cells: multispectral and molecular dynamic simulation analyses. Sci Rep. 2024 Nov 14;14 (1) :27985.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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