TDO2-IN-1

TDO2-IN-1 (Cpd-2) is a potent inhibitor of Human TDO2, with the IC50 of 14.8 nM. TDO2-IN-1 plays an important role in metabolism, inflammation, and tumor immune surveillance research[1].

Product Specifications

UNSPSC

12352005

Target

Indoleamine 2,3-Dioxygenase (IDO)

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Smiles

O=C1N2C(C(N([C@@H](C)C3=CC=CC=C3)C(NC4=CC=CC=C4C(C)C)=O)CCC2)=NC(OC)=C1C(OCC)=O

Molecular Formula

C30H36N4O5

Molecular Weight

532.63

References & Citations

[1]Carina Lotz-Jenne, et al. Discovery and binding mode of small molecule inhibitors of the apo form of human TDO2. Sci Rep. 2024 Nov 14;14 (1) :27937.