Ibetazol
Ibetazol is an inhibitor for importin β1 (KPNB1), that inhibits that binds to Cys585 of importin β1, inhibits the importin β1 mediated nuclear import with an EC50 of 6.1 µM[1].
Product Specifications
UNSPSC
12352005
Target
Ras
Related Pathways
GPCR/G Protein; MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Others
Purity
99.80
Solubility
DMSO : 10 mg/mL (ultrasonic)
Smiles
FC(F)(F)C1=CC(C2=CC=CC=C2)=NC(S(CC)=O)=N1
Molecular Formula
C13H11F3N2OS
Molecular Weight
300.30
References & Citations
[1]Vercruysse T, et al., Ibetazol, a novel inhibitor of importin β1-mediated nuclear import. Commun Biol. 2024 Nov 23;7 (1) :1560.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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