GLUT-1-IN-4
GLUT-1-IN-4 (Compound 13) is the p53 protein-dependent inhibitor for GLUT-1 glucose transporter. GLUT-1-IN-4 inhibits the proliferation of multiple cancer cells with IC50 in submicromolar levels. GLUT-1-IN-4 arrests the cell cycle, stimulates oxidative stress, and induces apoptosis[1].
Product Specifications
CAS Number
[735-16-0]
UNSPSC
12352005
Target
Apoptosis; GLUT; Reactive Oxygen Species (ROS)
Related Pathways
Apoptosis; Immunology/Inflammation; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; NF-κB
Field of Research
Cancer
Smiles
O=[N+]([O-])C1=CC=C(/C=C/C2=CC=NC3=CC=CC=C32)O1
Molecular Formula
C15H10N2O3
Molecular Weight
266.25
References & Citations
[1]Kuczak M, et al., 4-Furanylvinylquinoline derivative as a new scaffold for the design of oxidative stress initiator and glucose transporter inhibitor drugs. Sci Rep. 2024 Nov 18;14 (1) :28454.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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