AP-238

AP-238 is a a new synthetic opioid (NSO), and acts as an agonist for μ-opioid receptor (MOR) with an EC50 of 248 nM. AP-238 exhibits analgesic activity[1][2].

Product Specifications

CAS Number

[140924-11-4]

UNSPSC

12352005

Target

Opioid Receptor

Related Pathways

GPCR/G Protein; Neuronal Signaling

Field of Research

Neurological Disease

Smiles

CCC(N1[C@H](C)CN(C/C=C/C2=CC=CC=C2)C[C@@H]1C)=O

Molecular Formula

C18H26N2O

Molecular Weight

286.41

References & Citations

[1]Jurowski K, et, al. Prediction of key toxicity endpoints of AP-238 a new psychoactive substance for clinical toxicology and forensic purposes using in silico methods. Sci Rep. 2024 Nov 22;14 (1) :28977.|[2]Brunetti P, et al., Human metabolism and basic pharmacokinetic evaluation of AP-238: A recently emerged acylpiperazine opioid. Drug Test Anal. 2024 Feb;16 (2) :221-235.