NZ-804
NZ-804 is an orally active inhibitor for SARS-CoV-2 main protease Mpro with an IC50 of 8.9 nM. NZ-804 inhibits the SARS-CoV-2 replication in HeLa-hACE2 cell with an EC50 of 14 nM. NZ-804 exhibits board-spectrum antiviral activity aganst multiple CoVs. NZ-804 diminishes virus replication in mouse and hamster model[1].
Product Specifications
CAS Number
2858658-44-1
UNSPSC
12352005
Target
SARS-CoV; Virus Protease
Related Pathways
Anti-infection
Field of Research
Infection
Smiles
O=C(N1CC/C(CC1)=C2C3=C(CS(=O)(C4=C/2C=CC=C4)=O)C=CC=C3)C5=CN=CC6=C5NC=C6
Molecular Formula
C27H23N3O3S
Molecular Weight
469.55
References & Citations
[1]Zhou NE, et al., An oral non-covalent non-peptidic inhibitor of SARS-CoV-2 Mpro ameliorates viral replication and pathogenesis in vivo. Cell Rep. 2024 Nov 26;43 (11) :114929.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
MBS9005763 Inquire
Rabbit anti-Oryza sativa subsp. japonica (Rice) TULP2 Polyclonal Antibody
Sign In for Pricing
View Details ![Rabbit Monoclonal CNTF Antibody (121) [CoraFluor 1]](https://cdn.genprice.uk/genprice/uk/genprice3.webp)
NBP2-90839CL1 0.1 mL
Rabbit Monoclonal CNTF Antibody (121) [CoraFluor 1]
Sign In for Pricing
View Details 
MBS1013525 Inquire
Recombinant Bacillus subtilis UPF0053 protein yqhB (yqhB)
Sign In for Pricing
View Details