Gemcitabine-13C,15N2

Antimetabolite and an antineoplastic agent. Gemcitabine inhibits DNA synthesis and repair, resulting in autophagyand apoptosis[1][2].

Product Specifications

CAS Number

[1233921-74-8]

Product Name Alternative

LY 188011-13C,15N2

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; Autophagy; DNA/RNA Synthesis; Isotope-Labeled Compounds; Nucleoside Antimetabolite/Analog

Related Pathways

Apoptosis; Autophagy; Cell Cycle/DNA Damage; Others

Field of Research

Cancer

Purity

99.23

Smiles

NC(C=C[15N]1[C@H]2C(F)(F)[C@H](O)[C@@H](CO)O2)=[15N][13C]1=O

Molecular Formula

C8 13CH11F2N 15N2O4

Molecular Weight

266.18

Precautions

H302, H315, H319, H335

References & Citations

[1]Wang H, et al. Enhanced efficacy of Gemcitabine by indole-3-carbinol in pancreatic cell lines: the role of human equilibrativenucleoside transporter 1. Anticancer Res. 2011 Oct;31 (10) :3171-80. |[2]Gagnadoux F, et al. Safety of pulmonary administration of gemcitabine in rats. J Aerosol Med. 2005 Summer;18 (2) :198-206.