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Rifabutin-d6

Rifabutin-d6 (Ansamycin-d6) is deuterium labeled Rifabutin. Rifabutin (Ansamycin) is a semisynthetic ansamycin antibiotic with potent antimycobacterial properties. Rifabutin inhibits DNA-dependent RNA polymerase.

Product Specifications

Product Name Alternative

Ansamycin-d6; LM-427-d6

UNSPSC

12352005

Target

Antibiotic; Bacterial; Isotope-Labeled Compounds

Related Pathways

Anti-infection; Others

Applications

COVID-19-immunoregulation

Field of Research

Infection

Smiles

C[C@H]1/C=C/C=C(C)\C(/N=C2C(O)=C3C(C4=C(O[C@@](O/C=C/[C@H](OC)[C@@H](C)[C@@H](OC(C)=O)[C@H](C)[C@H](O)[C@H](C)[C@H]1O)(C)C4=O)C(C)=C3O)=C5C/2=NC6(CCN(CC(C([2H])([2H])[2H])C([2H])([2H])[2H])CC6)N5)=O

Molecular Formula

C46H56D6N4O11

Molecular Weight

853.04

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Review Article: Rifabutin in the Treatment of Refractory Helicobacter pylori Infection 
 J. P. Gisbert, X. Calvet Issue Alimentary Pharmacology & Therapeutics Volume 35, Issue 2, pages 209-221, January 2012|[3]Vourvahis M, Davis J, Wang R, Layton G, Choo HW, Chong CL, Tawadrous M.
 Effect of rifampin and rifabutin on the pharmacokinetics of lersivirine and effect of lersivirine on the pharmacokinetics of rifabutin and 25-o-desacetyl-rifabutin in healthy subjects.
 Antimicrob Agents Chemother. 2012 Aug;56 (8) :4303-9.|[4]Gisbert JP, Castro-Fernandez M, Perez-Aisa A, Cosme A, Molina-Infante J, Rodrigo L, Modolell I, Cabriada JL, Gisbert JL, Lamas E, Marcos E, Calvet X.
 Fourth-line rescue therapy with rifabutin in patients with three Helicobacter pylori eradication failures.
 Aliment Pharmacol Ther. 2012 Apr;35 (8) :941-7. doi: 10.1111/j.1365-2036.2012.05053.x.|[5]Gisbert JP, Calvet X.
 Review article: rifabutin in the treatment of refractory Helicobacter pylori infection.
 Aliment Pharmacol Ther. 2012 Jan;35 (2) :209-21. doi: 10.1111/j.1365-2036.2011.04937.x.|[6]Horne DJ, Spitters C, Narita M.
 Experience with rifabutin replacing rifampin in the treatment of tuberculosis.
 Int J Tuberc Lung Dis. 2011 Nov;15 (11) :1485-9, i.

Shipping Conditions

Room temperature

Scientific Category

Isotope-Labeled Compounds

Clinical Information

No Development Reported

Frequently Asked Questions

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