SIK2/3-IN-1

SIK2/3-IN-1 (Compound 7S) is a selectively inhibitory agent of SIK2/3 with oral activity. SIK2/3-IN-1 can significantly inhibit tumor growth (without any body weight loss) in the MV4-11 AML mice CDX model. SIK2/3-IN-1 can be used in the research of MEF2C-dependent acute myeloid leukemia[1].

Product Specifications

CAS Number

[3038863-24-7]

UNSPSC

12352005

Target

Salt-inducible Kinase (SIK)

Related Pathways

Immunology/Inflammation

Field of Research

Cancer

Smiles

O=C1N(CCC2=CC(C3=C(N=CC(C4=CN(N=C4)C)=C3)N)=NC(OC)=C12)CC(F)(F)F

Molecular Formula

C20H19F3N6O2

Molecular Weight

432.40

References & Citations

[1]Zhu W, et al. Discovery of Novel SIK2/3 Inhibitors for the Potential Treatment of MEF2C+ Acute Myeloid Leukemia (AML) . J Med Chem. 2025 Apr 10;68 (7) :7518-7538.