SIK2/3-IN-1
SIK2/3-IN-1 (Compound 7S) is a selectively inhibitory agent of SIK2/3 with oral activity. SIK2/3-IN-1 can significantly inhibit tumor growth (without any body weight loss) in the MV4-11 AML mice CDX model. SIK2/3-IN-1 can be used in the research of MEF2C-dependent acute myeloid leukemia[1].
Product Specifications
CAS Number
3038863-24-7
UNSPSC
12352005
Target
Salt-inducible Kinase (SIK)
Related Pathways
Immunology/Inflammation
Field of Research
Cancer
Smiles
O=C1N(CCC2=CC(C3=C(N=CC(C4=CN(N=C4)C)=C3)N)=NC(OC)=C12)CC(F)(F)F
Molecular Formula
C20H19F3N6O2
Molecular Weight
432.40
References & Citations
[1]Zhu W, et al. Discovery of Novel SIK2/3 Inhibitors for the Potential Treatment of MEF2C+ Acute Myeloid Leukemia (AML) . J Med Chem. 2025 Apr 10;68 (7) :7518-7538.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
SIK2; SIK3
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