NNOS-IN-5

NNOS-IN-5 (Compound 9) is a potent human neuronal NOS (nNOS) inhibitor (Ki = 22 nM) . nNOS-IN-5 exhibits excellent selectivity, with a 900-fold preference for human nNOS over human endothelial NOS (eNOS) . nNOS-IN-5 can be used for neurodegenerative diseases study, such as Alzheimer's disease and Parkinson’s disease[1].

Product Specifications

CAS Number

[2945955-27-9]

UNSPSC

12352005

Target

NO Synthase

Related Pathways

Immunology/Inflammation

Field of Research

Neurological Disease

Smiles

NC1=NC2=CC(COC3=CC=CC(CNCC4=NC=CC=C4)=C3)=CC=C2C=C1

Molecular Formula

C23H22N4O

Molecular Weight

370.45

References & Citations

[1]Weerawarna PM, et al. A Tetrahydrobiopterin-Displacing Potent Neuronal Nitric Oxide Synthase Inhibitor with an Unprecedented Binding Mode. ACS Med Chem Lett. 2025 Mar 21;16 (4) :651-659.