NNOS-IN-5
NNOS-IN-5 (Compound 9) is a potent human neuronal NOS (nNOS) inhibitor (Ki = 22 nM) . nNOS-IN-5 exhibits excellent selectivity, with a 900-fold preference for human nNOS over human endothelial NOS (eNOS) . nNOS-IN-5 can be used for neurodegenerative diseases study, such as Alzheimer's disease and Parkinson’s disease[1].
Product Specifications
CAS Number
2945955-27-9
UNSPSC
12352005
Target
NO Synthase
Related Pathways
Immunology/Inflammation
Field of Research
Neurological Disease
Smiles
NC1=NC2=CC(COC3=CC=CC(CNCC4=NC=CC=C4)=C3)=CC=C2C=C1
Molecular Formula
C23H22N4O
Molecular Weight
370.45
References & Citations
[1]Weerawarna PM, et al. A Tetrahydrobiopterin-Displacing Potent Neuronal Nitric Oxide Synthase Inhibitor with an Unprecedented Binding Mode. ACS Med Chem Lett. 2025 Mar 21;16 (4) :651-659.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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