NLRP3-IN-75
NLRP3-IN-75 is an orally active NLRP3 inhibitor. NLRP3-IN-75 suppresses IL-1β secretion (IC50 = 23 nM) . NLRP3-IN-75 selectively inhibits NLRP3 activation by disrupting inflammasome assembly without affecting NLRC4 or AIM2 inflammasomes. NLRP3-IN-75 exhibits superior efficacy in acute peritonitis, diabetic kidney disease and IBD models[1].
Product Specifications
UNSPSC
12352005
Target
Interleukin Related; NF-κB; NOD-like Receptor (NLR)
Related Pathways
Immunology/Inflammation; NF-κB
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Smiles
O=C(NC1=C2CCCC2=CC3=C1CCC3)NS(N(C4CCN(CC4)C)C)(=O)=O
Molecular Formula
C20H30N4O3S
Molecular Weight
406.54
References & Citations
[1]1. Liu Y, et al., Discovery of Novel Sulfonylurea NLRP3 Inflammasome Inhibitor for the Treatment of Multiple Inflammatory Diseases. J Med Chem.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
IL-1
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