C-Kit-IN-9
Kit-IN-9 (Compound D9) is an inhibitor of c-Kit. c-Kit-IN-9 inhibits the inflammatory responses in J774A.1, RAW264.7, MPMs cells and lung tissues by blocking the activation of the NF-κB pathway induced by LPS. Meanwhile, c-Kit-IN-9 exhibits good anti-inflammatory activities in acute lung injury and sepsis mouse models. c-Kit-IN-9 can be used in the research of acute lung injury and related inflammatory diseases[1].
Product Specifications
UNSPSC
12352005
Target
C-Kit
Related Pathways
Protein Tyrosine Kinase/RTK
Field of Research
Inflammation/Immunology
Smiles
O=C(C1=CC(OC2=CC=C(C=C2)NC(C3=CN(C4=C(C3=O)C=CC=C4)C5=CC=C(C=C5)F)=O)=CC=N1)NCCC6=CC=CS6
Molecular Formula
C34H25FN4O4S
Molecular Weight
604.65
References & Citations
[1]Luo W, et al. Discovery of c-Kit as a New Therapeutic Target in LPS-Induced Acute Lung Injury through Novel Phenylamide Derivative D9. J Med Chem. 2025 Apr 10;68 (7) :7499-7517.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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