NLRP3-IN-76

NLRP3-IN-76 is an orally active NLRP3 inhibitor. NLRP3-IN-76 inhibits the production of NO, and the mRNA levels of proinflammatory cytokines (iNOS, IL-6, IL-1β and TNFα) . NLRP3-IN-76 shows anti-inflammatory effects by inhibiting the activation of the NLRP3 inflammasome and NF-κB signaling pathway. NLRP3-IN-76 ameliorates DSS (HY-116282C) -induced colitis and can be used for research of inflammatory bowel diseases (IBD) [1].

Product Specifications

UNSPSC

12352005

Target

Interleukin Related; NF-κB; NO Synthase; NOD-like Receptor (NLR)

Related Pathways

Immunology/Inflammation; NF-κB

Field of Research

Inflammation/Immunology

Smiles

COC1=CC=C(C2=NC(C(NNC(C3=NC=CC=C3)=O)=O)=CO2)C=C1

Molecular Formula

C17H14N4O4

Molecular Weight

338.32

References & Citations

[1]Sun Z, et al. Discovery of novel Bis-amide analogue ST12 for the treatment of inflammatory bowel diseases (IBD) by inhibiting NLRP3 inflammasome activation. Bioorg Chem. 2025 Jun 1;159:108402.