NLRP3-IN-76
NLRP3-IN-76 is an orally active NLRP3 inhibitor. NLRP3-IN-76 inhibits the production of NO, and the mRNA levels of proinflammatory cytokines (iNOS, IL-6, IL-1β and TNFα). NLRP3-IN-76 shows anti-inflammatory effects by inhibiting the activation of the NLRP3 inflammasome and NF-κB signaling pathway. NLRP3-IN-76 ameliorates DSS -induced colitis and can be used for research of inflammatory bowel diseases (IBD).
Product Specifications
UNSPSC
12352005
Target
Interleukin Related; NF-κB; NO Synthase; NOD-like Receptor (NLR)
Related Pathways
Immunology/Inflammation; NF-κB
Field of Research
Inflammation/Immunology
Smiles
COC1=CC=C(C2=NC(C(NNC(C3=NC=CC=C3)=O)=O)=CO2)C=C1
Molecular Formula
C17H14N4O4
Molecular Weight
338.32
References & Citations
[1]Sun Z, et al. Discovery of novel Bis-amide analogue ST12 for the treatment of inflammatory bowel diseases (IBD) by inhibiting NLRP3 inflammasome activation. Bioorg Chem. 2025 Jun 1;159:108402.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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