SL-89.0591

SL-89.0591 is a uroselective α1-adrenoceptor antagonist. SL-89.0591 exhibits a more potent blocking effect on urethral receptors than on vascular receptors in anesthetized rabbits, with a lower risk of orthostatic hypotension. SL-89.0591 can be used in research related to benign prostatic hyperplasia[1].

Product Specifications

CAS Number

[194674-19-6]

UNSPSC

12352005

Target

Adrenergic Receptor

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Smiles

NC(C1=CC=NC(NCCCN2CCN(C3=C(OC)C=CC(Cl)=C3)CC2)=N1)=O

Molecular Formula

C19H25ClN6O2

Molecular Weight

404.89

References & Citations

[1]Hieble JP, et al. Effects of alpha1-adrenoceptor antagonists on agonist and tilt-induced changes in blood pressure: relationships to uroselectivity. Eur J Pharmacol. 1999 May 28;373 (1) :51-62.