(−) -Epigallocatechin Gallate-d3/d4

(-) -Epigallocatechin Gallate-d3/d4 (EGCG-d3/d4) is the deuterium labeled (-) -Epigallocatechin Gallate (HY-13653) . (-) -Epigallocatechin Gallate (EGCG) is a major polyphenol in green tea, which can inhibit cell proliferation and induce cell apoptosis. (-) -Epigallocatechin Gallate inhibits glutamate dehydrogenase 1/2 (GDH1/2, GLUD1/2) activity. (-) -Epigallocatechin Gallate has a potent anticancer, antioxidant and anti-inflammatory properties against various types of cancers such as colorectal cancer, myeloid leukemia, thyroid carcinoma[1][2][3][4].

Product Specifications

Product Name Alternative

EGCG-d3/d4; Epigallocatechol Gallate-d3/d4

UNSPSC

12352005

Target

Apoptosis; Isotope-Labeled Compounds

Related Pathways

Apoptosis; Others

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Inflammation/Immunology

Smiles

OC(C(O)=C1[2H])=C(C=C1[C@H]2OC(C=C(C=C3O)O)=C3C[C@H]2OC(C4=C(C(O)=C(C(O)=C4[2H])O)[2H])=O)O.OC(C(O)=C5[2H])=C(C([2H])=C5[C@H]6OC(C=C(C=C7O)O)=C7C[C@H]6OC(C8=C(C(O)=C(C(O)=C8[2H])O)[2H])=O)O

Molecular Formula

C22H15D3O11 (for d3)

Molecular Weight

461.39 (for d3)

References & Citations

[1]De Amicis F, et al. Epigallocatechin gallate inhibits growth and Epithelial-to-Mesenchymal Transition in human thyroid carcinoma cell lines. J Cell Physiol. 2013 Apr 1. |[2]Peeters TH, et al. Isocitrate dehydrogenase 1-mutated cancers are sensitive to the green tea polyphenol epigallocatechin-3-gallate. Cancer Metab. 2019 May 20;7:4.|[3]Jin H, et al. Epigallocatechin gallate inhibits the proliferation of colorectal cancer cells by regulating Notch signaling. Onco Targets Ther. 2013;6:145-53. |[4]Tsukasa Tominari; Epigallocatechin gallate (EGCG) suppresses lipopolysaccharide-induced inflammatory bone resorption, and protects against alveolar bone loss in mice. FEBS Open Bio. 2015 Jun 12;5:522-7.