(R) - (+) -Tolvaptan
(R) - (+) -Tolvaptan ((R) - (+) -OPC-41061) is the (R) - (+) enantiomer of Tolvaptan (HY-17000) . Tolvaptan (OPC-41061) is a selective, competitive and orally active vasopressin receptor 2 (V2R) antagonist[1][2].
Product Specifications
Product Name Alternative
(R) - (+) -OPC-41061
UNSPSC
12352005
Hazard Statement
H302
Target
Vasopressin Receptor
Related Pathways
GPCR/G Protein
Field of Research
Others
Smiles
O=C(NC1=CC=C(C(N2CCC[C@@H](O)C3=CC(Cl)=CC=C32)=O)C(C)=C1)C4=CC=CC=C4C
Molecular Formula
C26H25ClN2O3
Molecular Weight
448.94
Precautions
P264-P270-P330-P501
References & Citations
[1]Yin L, et al. Efficient and promising asymmetric preparation of enantiopure tolvaptan via transfer hydrogenation with robust catalysts[J]. Tetrahedron: Asymmetry, 2010, 21 (19) : 2390-2393.|[2]Wu Y, et al. Mechanisms of tolvaptan-induced toxicity in HepG2 cells. Biochem Pharmacol. 2015 Jun 15;95 (4) :324-36.
Shipping Conditions
Room temperature
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-17000A/
Scientific Category
Reference compound1
Clinical Information
No Development Reported
CAS Number
[331947-66-1]
Available Sizes
Curated Selection
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