(R) - (+) -Tolvaptan

(R) - (+) -Tolvaptan ((R) - (+) -OPC-41061) is the (R) - (+) enantiomer of Tolvaptan (HY-17000) . Tolvaptan (OPC-41061) is a selective, competitive and orally active vasopressin receptor 2 (V2R) antagonist[1][2].

Product Specifications

CAS Number

[331947-66-1]

Product Name Alternative

(R) - (+) -OPC-41061

UNSPSC

12352005

Hazard Statement

H302

Target

Vasopressin Receptor

Related Pathways

GPCR/G Protein

Field of Research

Others

Smiles

O=C(NC1=CC=C(C(N2CCC[C@@H](O)C3=CC(Cl)=CC=C32)=O)C(C)=C1)C4=CC=CC=C4C

Molecular Formula

C26H25ClN2O3

Molecular Weight

448.94

Precautions

P264-P270-P330-P501

References & Citations

[1]Yin L, et al. Efficient and promising asymmetric preparation of enantiopure tolvaptan via transfer hydrogenation with robust catalysts[J]. Tetrahedron: Asymmetry, 2010, 21 (19) : 2390-2393.|[2]Wu Y, et al. Mechanisms of tolvaptan-induced toxicity in HepG2 cells. Biochem Pharmacol. 2015 Jun 15;95 (4) :324-36.