BC13
BC13 is a CDK6/BRD4 inhibitor with the IC50 values of 234 nM and 36 nM for CDK6 and BRD4, respectively. BC13 shows antiproliferative activity and induces cell apoptosis and DNA damage. BC13 increases in ROS levels[1].
Product Specifications
CAS Number
3036645-03-8
UNSPSC
12352005
Target
Apoptosis; CDK; DNA/RNA Synthesis; Epigenetic Reader Domain; Reactive Oxygen Species (ROS)
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Epigenetics; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
COC1=C2C(NC(C3=CC=C(C=C3)C(N4CC5(C4)CCN(CC5)C6=NC(N7C8CCCC8)=C(C=N6)C(C)=CC7=O)=O)=NC2=CC(OC)=C1)=O
Molecular Formula
C37H39N7O5
Molecular Weight
661.75
References & Citations
[1]Zhang Y, et al. Discovery of Dual CDK6/BRD4 Inhibitor Inducing Apoptosis and Increasing the Sensitivity of Ferroptosis in Triple-Negative Breast Cancer. J Med Chem. 2024;67 (23) :21186-21207.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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