BC13

BC13 is a CDK6/BRD4 inhibitor with the IC50 values of 234 nM and 36 nM for CDK6 and BRD4, respectively. BC13 shows antiproliferative activity and induces cell apoptosis and DNA damage. BC13 increases in ROS levels[1].

Product Specifications

CAS Number

[3036645-03-8]

UNSPSC

12352005

Target

Apoptosis; CDK; DNA/RNA Synthesis; Epigenetic Reader Domain; Reactive Oxygen Species (ROS)

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Epigenetics; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Smiles

COC1=C2C(NC(C3=CC=C(C=C3)C(N4CC5(C4)CCN(CC5)C6=NC(N7C8CCCC8)=C(C=N6)C(C)=CC7=O)=O)=NC2=CC(OC)=C1)=O

Molecular Formula

C37H39N7O5

Molecular Weight

661.75

References & Citations

[1]Zhang Y, et al. Discovery of Dual CDK6/BRD4 Inhibitor Inducing Apoptosis and Increasing the Sensitivity of Ferroptosis in Triple-Negative Breast Cancer. J Med Chem. 2024;67 (23) :21186-21207.