TyK2-IN-21-d3

TyK2-IN-21-d3 (Compound 3c) is the orally active prodrug of the tyrosine kinase 2. TyK2-IN-21-d3 exhibits good chemical stability in aqueous system under different pHs. TyK2-IN-21-d3 alleviates the effect of gastric acid changes on drug absorption and improve the drug bioavailability in rat model[1].

Product Specifications

CAS Number

[2583719-08-6]

UNSPSC

12352005

Target

JAK

Related Pathways

Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Smiles

O=P(O)(OCN1C=C(C(NC([2H])([2H])[2H])=O)C(NC2=CC=CC(C3=NN(C)N=N3)=C2OC)=C/C1=N\C(C4CC4)=O)O

Molecular Formula

C21H22D3N8O7P

Molecular Weight

535.46

References & Citations

[1]A M Subbaiah M, et al., Prodrug Strategy to Address Impaired Oral Absorption of a Weakly Basic TYK2 Inhibitor Caused by a Gastric Acid-Reducing Agent. J Med Chem. 2024 Nov 28;67 (22) :20664-20681.