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PI3Kδ-IN-23

PI3Kδ-IN-23 (compound A11) is a potent inhibitor of PI3Kδ, with the IC50 of 0.27 nM. PI3Kδ-IN-23 bounds to PI3Kδ by covalent-bonding interactions with Lys779. PI3Kδ-IN-23 plays an important role in cancer research[1].

Product Specifications

CAS Number

3051828-81-7

UNSPSC

12352005

Target

PI3K

Related Pathways

PI3K/Akt/mTOR

Field of Research

Cancer

Smiles

O=C(OC1=CC=CC=C1)C2=CC(C3=NC(C(N[C@@H]4CN(CC4)C(C5CCOCC5)=O)=NC=N6)=C6C=C3)=CN=C2OC

Molecular Formula

C30H30N6O5

Molecular Weight

554.60

References & Citations

[1]Bo Yuan, et al. Lysine-Targeted Covalent Inhibitors of PI3Kδ Synthesis and Screening by In Situ Interaction Upgradation. J Med Chem. 2024 Nov 28;67 (22) :20076-20099.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

PI3Kδ

Frequently Asked Questions

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