SARS-CoV-2-IN-107
SARS-CoV-2-IN-107 (Compound A7) is the inhibitor for SARS-CoV-2 3CLpro with an IC50 of 261.3 nM. SARS-CoV-2-IN-107 inhibits the SARS-CoV-2 replication with an EC50 of 11.7 μM. SARS-CoV-2-IN-107 exhibits anti-inflammatory activity with a NO inhibition rate of 68.6% in LPS (HY-D1056) -stimulated RAW264.7 macrophages[1].
Product Specifications
UNSPSC
12352005
Target
NO Synthase; SARS-CoV; Virus Protease
Related Pathways
Anti-infection; Immunology/Inflammation
Field of Research
Infection; Inflammation/Immunology
Smiles
O=C(C1=CC=C(F)C=C1)/C=C/C2=CC(O)=C(O)C(O)=C2
Molecular Formula
C15H11FO4
Molecular Weight
274.24
References & Citations
[1]Chen X, et al., Discovery of Chalcone Derivatives as Bifunctional Molecules with Anti-SARS-CoV-2 and Anti-inflammatory Activities. J Nat Prod. 2024 Dec 27;87 (12) :2680-2694.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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