PhoPS
PhoPS is the photocaged inhibitor for β-lactamase. PhoPS is activated upon light irradiation, and active β-lactamase inhibitor Sulbactam is released. PhoPS inhibits the synthesis of bacterial cell wall and the formation of E. coli biofilm, exhibits antimicrobial activity[1].
Product Specifications
UNSPSC
12352005
Target
Bacterial; Beta-lactamase
Related Pathways
Anti-infection
Field of Research
Infection
Smiles
CC(COC(C(C1(C)C)N2C(CC2=O)S1(=O)=O)=O)C3=C([N+]([O-])=O)C=CC(C4=CC=C(OCCOCCOCCOCCN5N=NC=C5CCCO[C@@H]6O[C@H](CO)[C@@H]([C@@H]([C@H]6O)O)O)C=C4)=C3
Molecular Formula
C42H57N5O17S
Molecular Weight
935.99
References & Citations
[1]Ma Z, et al., Light-Activable Inhibitor Overcomes Antimicrobial Resistance and Regulates Antibacterial Activity. J Med Chem. 2024 Nov 28;67 (22) :20455-20466.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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