PDE1-IN-8
PDE1-IN-8 (Compound 3f) is the inhibitor for PDE1 with an IC50 of 11 nM. PDE1-IN-8 inhibits cAMP and cGMP signaling pathway, inhibits the differentiation and proliferation of cells into myofibroblast, and exhibits anti-fibrotic efficacy in Bleomycin (HY-17565) -induced rat pulmonary fibrosis model[1].
Product Specifications
UNSPSC
12352005
Target
Phosphodiesterase (PDE)
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Others
Smiles
ClC1=CC=CC(C(C)SC2=NC(C3=CC=C(S3)Cl)=C(C(N2)=O)C#N)=C1
Molecular Formula
C17H11Cl2N3OS2
Molecular Weight
408.32
References & Citations
[1]Jiang MY, et al., Discovery of Selective PDE1 Inhibitors with Anti-pulmonary Fibrosis Effects by Targeting the Metal Pocket. J Med Chem. 2024 Nov 28;67 (22) :20203-20213.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PDE1; PDE10; PDE2; PDE3; PDE4; PDE5; PDE7; PDE8; PDE9
Curated Selection
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