HCA I-IN-4

HCA I-IN-4 (Compound 14) is the inhibitor for carbonic anhydrase and cholinesterase, that inhibits hCA I, hCA II, AChE, and BChE with Ki of 29.94 nM, 17.72 nM, 21.21 nM, and 7.65 nMrespectively. hCA I-IN-4 exhibits cytotoxicity in BT-549 with IC50 of 16.59 μM[1].

Product Specifications

CAS Number

[3054159-56-4]

UNSPSC

12352005

Target

Carbonic Anhydrase; Cholinesterase (ChE)

Related Pathways

Metabolic Enzyme/Protease; Neuronal Signaling

Field of Research

Cancer; Neurological Disease

Smiles

N1(CC2=CN(C3=CC=CN=C3)N=N2)C4=CC=CC=C4C=CC5=CC=CC=C51

Molecular Formula

C22H17N5

Molecular Weight

351.40

References & Citations

[1]Erdoğan M, et al., Novel Dibenzoazepine-Substituted Triazole Hybrids as Cholinesterase and Carbonic Anhydrase Inhibitors and Anticancer Agents: Synthesis, Characterization, Biological Evaluation, and In Silico Studies. ACS Omega. 2024 Nov 16;9 (47) :46860-46878.