HCA I-IN-4
HCA I-IN-4 (Compound 14) is the inhibitor for carbonic anhydrase and cholinesterase, that inhibits hCA I, hCA II, AChE, and BChE with Ki of 29.94 nM, 17.72 nM, 21.21 nM, and 7.65 nMrespectively. hCA I-IN-4 exhibits cytotoxicity in BT-549 with IC50 of 16.59 μM[1].
Product Specifications
CAS Number
3054159-56-4
UNSPSC
12352005
Target
Carbonic Anhydrase; Cholinesterase (ChE)
Related Pathways
Metabolic Enzyme/Protease; Neuronal Signaling
Field of Research
Cancer; Neurological Disease
Smiles
N1(CC2=CN(C3=CC=CN=C3)N=N2)C4=CC=CC=C4C=CC5=CC=CC=C51
Molecular Formula
C22H17N5
Molecular Weight
351.40
References & Citations
[1]Erdoğan M, et al., Novel Dibenzoazepine-Substituted Triazole Hybrids as Cholinesterase and Carbonic Anhydrase Inhibitors and Anticancer Agents: Synthesis, Characterization, Biological Evaluation, and In Silico Studies. ACS Omega. 2024 Nov 16;9 (47) :46860-46878.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
AChE; BChE; CA II; CA I
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