WIZ degrader 8 (TFA)
WIZ degrader 8 (TFA) is the trifluoroacetic acid of WIZ degrader 8 (HY-169955) . WIZ degrader 8 (compound 10) is a potent and selective degrader of the transcription factor WIZ, which can potently induce HbF expression. WIZ degrader 8 can lead to WIZ degradation and induce HbF expression, and has the potential to be an inhibitor of sickle cell disease[1].
Product Specifications
UNSPSC
12352005
Target
Histone Acetyltransferase; Molecular Glues
Related Pathways
Epigenetics; PROTAC
Field of Research
Cardiovascular Disease
Purity
99.41
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C1N(C2C(NC(CC2)=O)=O)CC3=CC(O[C@H]4CN(C[C@@H](C4)C)CC)=CC=C31.OC(C(F)(F)F)=O
Molecular Formula
C23H28F3N3O6
Molecular Weight
499.48
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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