WIZ degrader 8
WIZ degrader 8 (compound 10) is a potent and selective degrader of the transcription factor WIZ, which can potently induce HbF expression. WIZ degrader 8 can lead to WIZ degradation and induce HbF expression, and has the potential to be an inhibitor of sickle cell disease[1].
Product Specifications
CAS Number
2879251-26-8
UNSPSC
12352005
Target
Histone Acetyltransferase; Molecular Glues
Related Pathways
Epigenetics; PROTAC
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Smiles
O=C1N(C2C(NC(CC2)=O)=O)CC3=CC(O[C@H]4CN(C[C@@H](C4)C)CC)=CC=C31
Molecular Formula
C21H27N3O4
Molecular Weight
385.46
References & Citations
[1]Kerrigan JR, et al. Discovery and Optimization of First-in-Class Molecular Glue Degraders of the WIZ Transcription Factor for Fetal Hemoglobin Induction to Treat Sickle Cell Disease. J Med Chem. 2024 Nov 28;67 (22) :20682-20694.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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