WIZ degrader 8

WIZ degrader 8 (compound 10) is a potent and selective degrader of the transcription factor WIZ, which can potently induce HbF expression. WIZ degrader 8 can lead to WIZ degradation and induce HbF expression, and has the potential to be an inhibitor of sickle cell disease[1].

Product Specifications

CAS Number

[2879251-26-8]

UNSPSC

12352005

Target

Histone Acetyltransferase; Molecular Glues

Related Pathways

Epigenetics; PROTAC

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Smiles

O=C1N(C2C(NC(CC2)=O)=O)CC3=CC(O[C@H]4CN(C[C@@H](C4)C)CC)=CC=C31

Molecular Formula

C21H27N3O4

Molecular Weight

385.46

References & Citations

[1]Kerrigan JR, et al. Discovery and Optimization of First-in-Class Molecular Glue Degraders of the WIZ Transcription Factor for Fetal Hemoglobin Induction to Treat Sickle Cell Disease. J Med Chem. 2024 Nov 28;67 (22) :20682-20694.