BT-Amide
BT-Amide is the orally active inhibitor for Pyk2 kinase with IC50 of 44.69 nM. BT-Amide prevents glucocorticoid-induced bone loss, exhibits bone protective activity in C57BL/6 mouse[1].
Product Specifications
UNSPSC
12352005
Target
Pyk2
Related Pathways
Protein Tyrosine Kinase/RTK
Field of Research
Metabolic Disease
Smiles
ClC1=C(N=C(N=C1)NC2=CC=C(C=C2OC)NC(CCCCC(NCCCC(P(O)(O)=O)(P(O)(O)=O)O)=O)=O)NC3=C(C=CC=C3)C(NC)=O
Molecular Formula
C29H38ClN7O11P2
Molecular Weight
758.05
References & Citations
[1]Wang X, et al., Generation of BT-Amide, a Bone-Targeted Pyk2 Inhibitor, Effective via Oral Administration, for the Prevention of Glucocorticoid-Induced Bone Loss. J Med Chem. 2024 Nov 28;67 (22) :20708-20720.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
A12345-1-iFluor647 100 µg
Anti-FATP3/SLC27A3 Antibody Picoband®, iFluor647 Conjugate
Sign In for Pricing
View Details 
SPC-720D-APC 100 µg
DYKDDDDK Tag Antibody (Equivalent to Sigma's Anti-FLAG® M2 Antibody) : APC
Sign In for Pricing
View Details 
123774-APC 100 µL
B3GAT3 (Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3, Beta-1,3-glucuronyltransferase 3, Glucuronosyltransferase I, UDP-GlcUA:Gal beta-1,3-Gal-R glucuronyltransferase) (APC)
Sign In for Pricing
View Details MBS6307869-01 0.2 mL
Hoxb6, NT (Hoxb6, Hox-2.2, Hoxb-6, Homeobox protein Hox-B6, Homeobox protein Hox-2.2, Homeobox protein MH-22A) (AP)
Sign In for Pricing
View Details MBS6307869-02 5x 0.2 mL
Hoxb6, NT (Hoxb6, Hox-2.2, Hoxb-6, Homeobox protein Hox-B6, Homeobox protein Hox-2.2, Homeobox protein MH-22A) (AP)
Sign In for Pricing
View Details