RORγt inverse agonist 33
RORγt inverse agonist 33 (compound (R) -D4) is an orally bioavailable and inverse agonists of RORγt, with the IC50 of 21 nM. RORγt inverse agonist 33 plays an important role in rheumatoid arthritis research[1].
Product Specifications
UNSPSC
12352005
Target
ROR
Related Pathways
Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Field of Research
Inflammation/Immunology
Smiles
OCC(C=C(S(N1C2=CC=C(C(C)C)C=C2CC[C@H]1CC)(=O)=O)C=C3)=C3COC4CCOCC4
Molecular Formula
C27H37NO5S
Molecular Weight
487.65
References & Citations
[1]Shan-Liang Sun, et al. Discovery of 1- (Phenylsulfonyl) -1,2,3,4-tetrahydroquinoline Derivative as Orally Bioavailable and Safe RORγt Inverse Agonists for Potential Treatment of Rheumatoid Arthritis. J Med Chem. 2024 Nov 28;67 (22) :20315-20342.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
RORγ
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