NMDA agonist 1

NMDA agonist 1 (compound 42d) is a potent NMDA agonist with a Ki value of 96 nM. NMDA agonist 1 acts as a partial agonist of the GluN1/GluN2B complex with an EC50 value of 78 nM[1].

Product Specifications

CAS Number

[2576586-47-3]

UNSPSC

12352005

Target

IGluR

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Field of Research

Neurological Disease

Smiles

O=C([C@@H](CNC(C1=CC2=NC=CC(C)=C2S1)=O)N)O

Molecular Formula

C12H13N3O3S

Molecular Weight

279.31

References & Citations

[1]Ascic E, et al. Advancements in NMDA Receptor-Targeted Antidepressants: From d-Cycloserine Discovery to Preclinical Efficacy of Lu AF90103. J Med Chem. 2024 Nov 28;67 (22) :20135-20155.