NMDA agonist 1
NMDA agonist 1 (compound 42d) is a potent NMDA agonist with a Ki value of 96 nM. NMDA agonist 1 acts as a partial agonist of the GluN1/GluN2B complex with an EC50 value of 78 nM[1].
Product Specifications
CAS Number
[2576586-47-3]
UNSPSC
12352005
Target
IGluR
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Field of Research
Neurological Disease
Smiles
O=C([C@@H](CNC(C1=CC2=NC=CC(C)=C2S1)=O)N)O
Molecular Formula
C12H13N3O3S
Molecular Weight
279.31
References & Citations
[1]Ascic E, et al. Advancements in NMDA Receptor-Targeted Antidepressants: From d-Cycloserine Discovery to Preclinical Efficacy of Lu AF90103. J Med Chem. 2024 Nov 28;67 (22) :20135-20155.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
NMDA Receptor
Curated Selection
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