BML-265
BML-265 is a potent EGFR tyrosine kinase inhibitor. BML-265 disrupts Golgi integrity and abolishes secretory protein transport of diverse cargos. BML-265 affects Golgi integrity and transport in human cells but not in rodent cells[1].
Product Specifications
CAS Number
[183321-62-2]
UNSPSC
12352005
Target
EGFR
Related Pathways
JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Smiles
COC1=C(OC)C=C(N=CN=C2NC3=CC=CC(C#C)=C3)C2=C1
Molecular Formula
C18H15N3O2
Molecular Weight
305.33
References & Citations
[1]Boncompain G, et al. BML-265 and Tyrphostin AG1478 Disperse the Golgi Apparatus and Abolish Protein Transport in Human Cells. Front Cell Dev Biol. 2019 Oct 11;7:232.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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