DDO-6079
DDO-6079 is a potent CDC37 inhibitor. DDO-6079 inhibits HSP90-CDC37 and CDC37-CDK4/6 chaperone complex by binding to an allosteric site on CDC37. DDO-6079 decreases the thermostability of CDK6[1].
Product Specifications
CAS Number
2648334-53-4
UNSPSC
12352005
Target
CDK
Related Pathways
Cell Cycle/DNA Damage
Field of Research
Cancer
Concentration
10mM
Purity
98.92
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C1=CC(Cl)=CC=C1O)NC2=CC(OC3=CC=CC=C3)=NC=C2
Molecular Formula
C18H13ClN2O3
Molecular Weight
340.76
References & Citations
[1]Zhang L, et al. Allosteric CDC37 Inhibitor Disrupts Chaperone Complex to Block CDK4/6 Maturation. Angew Chem Int Ed Engl. 2024 Nov 24:e202413618.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CDC
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
MBS6319964-01 0.1 mL
MED17, ID (MED17, ARC77, CRSP6, DRIP77, DRIP80, TRAP80, Mediator of RNA polymerase II transcription subunit 17, Activator-recruited cofactor 77kD component, Cofactor required for Sp1 transcriptional activation subunit 6, Mediator complex subunit 17, Thyro
Sign In for Pricing
View Details MBS6319964-02 5x 0.1 mL
MED17, ID (MED17, ARC77, CRSP6, DRIP77, DRIP80, TRAP80, Mediator of RNA polymerase II transcription subunit 17, Activator-recruited cofactor 77kD component, Cofactor required for Sp1 transcriptional activation subunit 6, Mediator complex subunit 17, Thyro
Sign In for Pricing
View Details 